What materials are Mann Welding chromatography columns built from?

Columns are fabricated in 316L stainless steel, C-22 Hastelloy, or acrylic, selected for chemical compatibility, cleanliness standards, visibility, and cost targets.

What column diameters and sizes do you manufacture?

Standard inner diameters range from 45 cm to 180 cm, with custom sizes and bed heights engineered to your specific process requirements.

Are your columns suitable for GMP pharmaceutical manufacturing?

Yes. We support hygienic, GMP-ready design with electropolished finishes and IQ/OQ documentation packages suitable for regulated manufacturing environments.

Do you provide ASME-coded pressure vessels and validation documentation?

Mann Welding is an ASME-certified fabricator. We provide IQ/OQ documentation packages and polymeric materials meeting USP Class VI requirements when specified.

Where are Mann Welding chromatography columns manufactured?

Every column and hydraulic control unit is designed and fabricated in the USA at our Chattanooga, Tennessee facility, supporting supply-chain security for US and global pharma.

Stainless Steel Chromatography Columns for GMP and Industrial Scale

316L Stainless · C-22 Hastelloy · Acrylic

Mann Welding designs and manufactures fully customizable chromatography columns built to match your process, facility constraints, and validation requirements. From pilot to production scale, we engineer columns around your target bed height, inner diameter, pressure profile, media, and cleaning approach so you can pack, run, and turn equipment faster with repeatable performance.

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Multiple Mann Welding 316L stainless steel industrial chromatography columns in a pharmaceutical cleanroom.

Chromatography column sizing graphic showing inner diameters from 45 to 180 cm.

Inner diameters (cm): 45 · 60 · 80 · 120 · 140 · 160 · 180 (and custom sizes by request)

Overview

Every Mann Welding column is engineered as a made-to-fit system. Choose the material, set your inner diameter and bed height, and specify the process details that matter most (packing method, pressure limits, cleaning strategy, sanitary interfaces, and documentation). The result is a column that integrates cleanly into your facility and supports consistent, repeatable separations at scale.

Custom scale: 45 cm to 180 cm inner diameter (ID); bed height built to spec
Pressure rating: sized to your column and process requirements
Materials: 316L stainless steel, C-22 Hastelloy, or acrylic
Hygienic design: finishes that reduce hold-up and support GMP operations
Qualification support: IQ/OQ documentation packages available
Materials compliance: polymeric materials meeting USP Class VI (when specified)

Need a customized solution?

Let us know what your product specifications require and we can produce a custom chromatography column based on your requirements.

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Built for repeatable, validation-ready performance

Inner diameter: 45–180 cm (custom sizes by request)
Bed height: Built to your process requirements
Materials: 316L stainless, C-22 Hastelloy, acrylic
Finishes: Electropolished, GMP-ready design paths
Validation: IQ/OQ documentation packages available

FAQ

Chromatography column questions, answered

What materials are Mann Welding chromatography columns built from?: Columns are fabricated in 316L stainless steel, C-22 Hastelloy, or acrylic, selected for chemical compatibility, cleanliness standards, visibility, and cost targets.
What column diameters and sizes do you manufacture?: Standard inner diameters range from 45 cm to 180 cm, with custom sizes and bed heights engineered to your specific process requirements.
Are your columns suitable for GMP pharmaceutical manufacturing?: Yes. We support hygienic, GMP-ready design with electropolished finishes and IQ/OQ documentation packages suitable for regulated manufacturing environments.
Do you provide ASME-coded pressure vessels and validation documentation?: Mann Welding is an ASME-certified fabricator. We provide IQ/OQ documentation packages and polymeric materials meeting USP Class VI requirements when specified.
Where are Mann Welding chromatography columns manufactured?: Every column and hydraulic control unit is designed and fabricated in the USA at our Chattanooga, Tennessee facility, supporting supply-chain security for US and global pharma.

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Digital HCU

PLC-driven, recipe-based control with closed-loop pressure, audit trails, and electronic records.

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Contact Sales

Looking for specs, pricing, or guidance on which chromatography column is right for your application? Our sales team is here to answer questions, provide technical details, and help you get the right solution in place.

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Contact Support

Already working with a Mann Welding column and need assistance? Our support team can help with components, maintenance, and troubleshooting so your systems stay running at peak performance.

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