Industrial Scale
Columns built to meet the demands of large-batch pharmaceutical manufacturing.
Custom Chromatography Columns & HCUs for GMP and Industrial Scale
Request a QuoteMann Welding designs and manufactures fully customizable chromatography columns built to match your process, facility constraints, and validation requirements. From pilot to production scale, we engineer columns around your target bed height, inner diameter, pressure profile, media, and cleaning approach.
Columns can be built in 316L stainless steel, C-22 Hastelloy, or acrylic, and paired with a mechanical or digital hydraulic control unit (HCU). We also support IQ/OQ documentation packages and hygienic design practices for regulated manufacturing.
- Inner diameter (ID): 45 cm to 180 cm (and custom sizes by request)
- Bed height: built to your process requirements (custom)
- Materials: 316L stainless, C-22 Hastelloy, acrylic (based on application)
- Hygienic options: electropolished finishes and GMP-ready design paths
- Validation support: IQ/OQ documentation packages available
- ASME-coded fabrication, made in the USA
Choose your product
Stainless Steel Columns
Custom 316L, C-22 Hastelloy, or acrylic columns from 45–180 cm ID — ASME-coded and GMP-ready.
Best for: Pilot-to-production GMP separations
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Mechanical HCU
Rugged manual control for reliable, software-free column packing and operation.
Best for: Pilot plants & teams that value manual oversight
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Digital HCU
PLC-driven, recipe-based control with closed-loop pressure, audit trails, and electronic records.
Best for: GMP lines needing electronic records & integration
Learn more →Chromatography Columns
Patented Technology
Innovations such as slurry fill methods, variable speed operation, and integrated hydraulic systems.
Engineered for Reliability
Straightforward column setup, PLC controlled leveling, and repeatable recipes.
FAQ
Chromatography column questions, answered
- What materials are Mann Welding chromatography columns built from?
- Columns are fabricated in 316L stainless steel, C-22 Hastelloy, or acrylic, selected for chemical compatibility, cleanliness standards, visibility, and cost targets.
- What column diameters and sizes do you manufacture?
- Standard inner diameters range from 45 cm to 180 cm, with custom sizes and bed heights engineered to your specific process requirements.
- Are your columns suitable for GMP pharmaceutical manufacturing?
- Yes. We support hygienic, GMP-ready design with electropolished finishes and IQ/OQ documentation packages suitable for regulated manufacturing environments.
- Do you provide ASME-coded pressure vessels and validation documentation?
- Mann Welding is an ASME-certified fabricator. We provide IQ/OQ documentation packages and polymeric materials meeting USP Class VI requirements when specified.
- Where are Mann Welding chromatography columns manufactured?
- Every column and hydraulic control unit is designed and fabricated in the USA at our Chattanooga, Tennessee facility, supporting supply-chain security for US and global pharma.
Contact Us
Contact Sales
Looking for specs, pricing, or guidance on which chromatography column is right for your application? Our sales team is here to answer questions, provide technical details, and help you get the right solution in place.
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Already working with a Mann Welding column and need assistance? Our support team can help with components, maintenance, and troubleshooting so your systems stay running at peak performance.
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